Description

4-Nitro-2-(Trifluoromethyl)Phenyl Isocyanate is a versatile and highly reactive aromatic isocyanate building block, distinguished by the presence of both electron-withdrawing nitro and trifluoromethyl substituents. This unique structure makes it a critical intermediate for synthesizing advanced chemical compounds with tailored properties. It is essential for R&D and production in industries such as pharmaceuticals, agrochemicals, and specialty polymers, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring urea or carbamate functional groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its bio-active scaffold.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating high-performance polyurethanes, coatings, and adhesives with enhanced chemical resistance.
• Chemical Research: A valuable reagent in organic synthesis for constructing heterocycles and other complex molecules via reactions with amines and alcohols.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of specialized dyes and pigments where the nitro and trifluoromethyl groups influence color and stability.

Basic Information

Product Name	4-Nitro-2-(Trifluoromethyl)Phenyl Isocyanate
CAS No.	16588-73-1
Molecular Formula	C8H3F3N2O3
Molecular Weight	232.12 g/mol
Synonyms	2-Trifluoromethyl-4-nitrophenyl isocyanate; 4-Nitro-α,α,α-trifluoro-o-tolyl isocyanate; 1-Isocyanato-4-nitro-2-(trifluoromethyl)benzene; 4-Nitro-2-trifluoromethylphenyl isocyanate; 2-(Trifluoromethyl)-4-nitrophenyl isocyanate; NSC 403087; 4-Nitro-2-trifluoromethyl phenyl isocyanate
EINECS	Contact for details

Quality Control

Our 4-Nitro-2-(Trifluoromethyl)Phenyl Isocyanate is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.