Description

Podophyllotoxin Glucoside is a glycosidic derivative of the potent natural lignan, podophyllotoxin. This compound serves as a crucial intermediate and reference standard in pharmaceutical research and development, particularly in the synthesis and study of chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on oncology drug discovery and botanical extract standardization.

Application

• Pharmaceutical Intermediate: Key starting material or precursor in the semi-synthesis of anticancer drugs such as etoposide and teniposide.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for the identification and quantification of podophyllotoxin-related compounds in raw materials and finished products.
• Biochemical Research: Employed in pharmacological studies to investigate mechanisms of action related to topoisomerase II inhibition and cell cycle arrest.
• Botanical Extract Analysis: Essential for standardizing and profiling complex plant extracts from Podophyllum species (e.g., Mayapple) in the nutraceutical and herbal medicine industries.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) of lignan derivatives and developing novel therapeutic agents.

Basic Information

Product Name	Podophyllotoxin Glucoside
CAS No.	16481-54-2
Molecular Formula	C28H32O13
Molecular Weight	576.55 g/mol
Synonyms	Podophyllotoxin β-D-glucoside; 4'-Demethylepipodophyllotoxin β-D-glucopyranoside; Picropodophyllin glucoside; NSC 405124; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one β-D-glucopyranoside; β-D-Glucopyranoside, (5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
EINECS	Contact for details

Quality Control

Our Podophyllotoxin Glucoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for use as a pharmaceutical intermediate and analytical reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.