Description

Proline, 2-Methyl-, Ethyl Ester, L- (8Ci) is a high-purity, non-proteinogenic amino acid derivative, specifically the ethyl ester of L-2-methylproline. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce structural complexity and stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptidomimetics Research: Used to synthesize modified peptide structures (peptidomimetics) to enhance metabolic stability, bioavailability, and receptor selectivity in drug discovery.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective organic reactions to construct complex molecular architectures.
• Biochemical Research: Employed in studies of enzyme mechanisms, protein structure-function relationships, and as a substrate analog in biochemical assays.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	Proline, 2-Methyl-, Ethyl Ester, L- (8Ci)
CAS No.	16277-08-0
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	L-2-Methylproline ethyl ester; Ethyl L-2-methylpyrrolidine-2-carboxylate; (2S)-2-Methylpyrrolidine-2-carboxylic acid ethyl ester; L-2-Methylproline ethyl ester hydrochloride (salt form); 2-Methyl-L-proline ethyl ester; NSC 163046; Ethyl (S)-2-methylpyrrolidine-2-carboxylate; 2-Pyrrolidinecarboxylic acid, 2-methyl-, ethyl ester, (2S)-
EINECS	Contact for details

Quality Control

Our Proline, 2-Methyl-, Ethyl Ester, L- (8Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.