Description

(4-Bromophenylethynyl)Trimethylsilane CAS NO 16116-78-2 is a versatile organosilicon building block featuring both a bromoaryl group and a protected terminal alkyne. This compound is essential for advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those requiring Sonogashira or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of novel pesticides and herbicides by constructing conjugated aromatic-alkyne systems.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and polymers where precise conjugation length and electronic properties are critical.
• Chemical Synthesis: Acts as a protected acetylene equivalent in multi-step organic synthesis, with the trimethylsilyl (TMS) group allowing for selective deprotection.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for metal-organic frameworks (MOFs) and homogeneous catalysis.
• Academic & R&D: A fundamental reagent in university and corporate research laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	(4-Bromophenylethynyl)Trimethylsilane
CAS No.	16116-78-2
Molecular Formula	C11H13BrSi
Molecular Weight	253.21 g/mol
Synonyms	1-Bromo-4-[(trimethylsilyl)ethynyl]benzene; 4-Bromophenyl(trimethylsilyl)acetylene; p-Bromophenylethynyltrimethylsilane; Trimethyl((4-bromophenyl)ethynyl)silane; 4-Bromo-1-[(trimethylsilyl)ethynyl]benzene; TMS-Protected 4-Bromophenylacetylene; (p-Bromophenylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our (4-Bromophenylethynyl)Trimethylsilane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.