Description

n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester is a highly functionalized, silyl-protected derivative of the essential amino acid L-glutamic acid. This compound is a critical intermediate in advanced organic synthesis, particularly in peptide chemistry and the production of complex pharmaceuticals, where it serves as a protected building block to prevent unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, specialized reagents for sophisticated synthetic routes.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of peptide-based drugs, prodrugs, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to protect the carboxylic acid and amino functionalities of glutamic acid, enabling selective coupling reactions.
• Organometallic & Catalysis Research: Serves as a ligand precursor or a substrate in reactions involving silicon chemistry and transition metal catalysis.
• Advanced Material Synthesis: A building block for creating specialized polymers, dendrimers, or surface-modified materials with specific functional groups.
• Bioconjugation Chemistry: Useful in the development of linker molecules or modified biomolecules for drug delivery systems and diagnostic agents.
• Analytical Reference Standard: Employed as a high-purity standard in analytical methods (e.g., HPLC, GC-MS) for quality control in pharmaceutical development.

Basic Information

Product Name	n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester
CAS No.	15985-07-6
Molecular Formula	C16H37NO4Si3
Molecular Weight	391.71 g/mol
Synonyms	L-Glutamic Acid, N-(trimethylsilyl)-, bis(trimethylsilyl) ester; N-Trimethylsilyl-L-glutamic Acid Bis(trimethylsilyl) Ester; N-TMS-L-Glutamic Acid Bis-TMS Ester; (S)-2-((Trimethylsilyl)amino)pentanedioic Acid Bis(trimethylsilyl) Ester; Glutamic Acid N-TMS Bis-TMS Ester; Protected L-Glutamic Acid TMS Ester; 15985-07-6
EINECS	Contact for details

Quality Control

Our n-(Trimethylsilyl)-L-Glutamic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.