Description

Trimethylsilyl Dl-Norvaline is a protected amino acid derivative where the carboxylic acid group is functionalized with a trimethylsilyl (TMS) group. This modification is crucial for enhancing solubility in organic solvents and preventing unwanted side reactions during complex synthetic sequences, particularly in peptide and pharmaceutical manufacturing. It serves as a key chiral building block and synthetic intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced material sectors. The compound is valued for its role in facilitating efficient multi-step organic syntheses where precise control over functional group reactivity is required.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Chemistry: Acts as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators.
• Chiral Synthesis: Utilized in asymmetric synthesis to introduce the norvaline moiety into complex molecular architectures.
• Material Science: Potential precursor for functionalized surfaces or specialty polymers requiring amino acid components.
• Bioconjugation: Employed in the modification of biomolecules where a protected carboxylic acid functionality is needed.
• Chemical Biology Probes: Used in the development of labeled or tagged amino acid analogs for mechanistic studies.
• Academic & Industrial R&D: A versatile reagent for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	Trimethylsilyl Dl-Norvaline
CAS No.	15984-95-9
Molecular Formula	C11H25NO2Si
Molecular Weight	231.41 g/mol
Synonyms	DL-Norvaline, Trimethylsilyl Ester; 2-((Trimethylsilyl)oxy)-2-oxoethylpentylamine; Trimethylsilyl 2-amino-pentanoate; Norvaline TMS ester; TMS-Norvaline; (RS)-2-Aminopentanoic Acid Trimethylsilyl Ester; Pentanoic acid, 2-amino-, trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Dl-Norvaline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.