Description

tert-Butyl 2-Aminobutanoate is a protected amino acid ester derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a sterically hindered tert-butyl ester group, which offers enhanced stability under various reaction conditions compared to methyl or ethyl esters. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of peptides, peptidomimetics, and other complex bioactive molecules where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative to prevent racemization.
• Protease Inhibitor Development: Serves as a core structure or precursor in the design and synthesis of enzyme inhibitors.
• Asymmetric Synthesis: Employed in the construction of complex natural products and chiral compounds requiring the (S)-2-aminobutanoic acid moiety.
• Bioconjugation & Labeling: Useful in preparing modified amino acids for bioconjugation strategies and probe development.
• Agrochemical Research: Potential intermediate in the synthesis of chiral herbicides or fungicides.

Basic Information

Product Name	tert-Butyl 2-Aminobutanoate
CAS No.	15911-72-5
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	(S)-tert-Butyl 2-aminobutanoate; L-2-Aminobutanoic acid tert-butyl ester; tert-Butyl L-2-aminobutanoate; tert-Butyl (S)-2-aminobutanoate; (S)-2-((tert-Butoxycarbonyl)amino)butanoic acid (common misnomer for Boc-protected form); Butanoic acid, 2-amino-, 1,1-dimethylethyl ester; 2-Aminobutanoic acid tert-butyl ester; H-α-Abu-OtBu
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Aminobutanoate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Specifications can be aligned with customer requirements for research, development, or cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.