Description

N,n-Bis(Trimethylsilyl)Formamide is a highly reactive organosilicon reagent primarily used as a powerful silylating agent. Its value lies in its ability to efficiently introduce the trimethylsilyl (TMS) protecting group onto sensitive functional groups like hydroxyls and amines, facilitating complex synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise protection and deprotection steps are critical for synthesizing high-value intermediates and active ingredients. Its properties make it a key tool for organic synthesis under anhydrous conditions.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting agent for hydroxyl and amino groups during the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of pesticides and herbicides where sensitive functional groups require protection from harsh reaction conditions.
• Peptide Chemistry: Facilitates the synthesis and modification of peptides by protecting amino acid side chains, preventing unwanted side reactions.
• Silicon-Based Polymer Research: Acts as a monomer or modifying agent in the development of specialized silicones and silicon-containing polymers.
• Analytical Derivatization: Used to silylate compounds for Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis, improving volatility and detection.
• Nucleoside and Carbohydrate Chemistry: Protects hydroxyl groups on sugar moieties during the synthesis of nucleosides, nucleotides, and modified carbohydrates.

Basic Information

Product Name	N,n-Bis(Trimethylsilyl)Formamide
CAS No.	15500-60-4
Molecular Formula	C7H19NOSi2
Molecular Weight	189.40 g/mol
Synonyms	Bis(trimethylsilyl)formamide; N,O-Bis(trimethylsilyl)formamide; BSA (common abbreviation); Formamide, N,N-bis(trimethylsilyl)-; 1,1,1,3,3,3-Hexamethyl-2-aza-1,3-disilaprop-1-ene; N,N-Bis(trimethylsilyl)formamid; TMS2NCHO; Hexamethyldisilazane derivative
EINECS	Contact for details

Quality Control

Our N,n-Bis(Trimethylsilyl)Formamide is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including assay by GC or NMR and purity verification, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.