Description

Estetrol is a naturally occurring estrogenic steroid hormone, also known as E4, with the CAS registry number 15183-37-6. It is a selective estrogen receptor modulator (SERM) with a unique pharmacological profile, offering a favorable benefit-risk ratio for therapeutic applications. This compound is of significant interest to the pharmaceutical industry for the development of novel hormone replacement therapies (HRT) and oral contraceptives, as well as to research institutions conducting endocrinology and oncology studies.

Application

• Pharmaceutical Active Ingredient (API): Core component in next-generation oral contraceptives and menopausal hormone therapy formulations.
• Hormone Replacement Therapy (HRT): Used in clinical research and drug development for treating menopausal symptoms like hot flashes and vaginal atrophy.
• Selective Estrogen Receptor Modulation: Serves as a reference compound in studies investigating tissue-specific estrogenic and anti-estrogenic effects.
• Oncology Research: Investigated for its potential role in hormone-sensitive cancers, including breast and prostate cancer research.
• Endocrinology & Metabolic Studies: Utilized in preclinical and clinical research to understand estrogen's impact on bone density, cardiovascular health, and lipid metabolism.
• Reference Standard: High-purity grade is essential for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Item	Detail
Product Name	Estetrol
CAS No.	15183-37-6
Molecular Formula	C18H24O4
Molecular Weight	304.38 g/mol
Synonyms	E4; Estetrol; 15α-Hydroxyestriol; 3,16α,17β-Trihydroxyestra-1,3,5(10)-trien-15-one; 1,3,5(10)-Estratrien-3,15α,16α,17β-tetrol; NSC 65977; Oestetrol
EINECS	Contact for details

Quality Control

Our Estetrol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with relevant pharmaceutical development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, storage at 2-8°C is recommended. Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.