Description

18-Nor-17β-Estradiol is a synthetic steroid derivative of the natural hormone estradiol, distinguished by the absence of the 18-methyl group. This structural modification is of significant interest in pharmaceutical research for developing novel therapeutic agents and biochemical probes. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on endocrinology, oncology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs) targeting hormone-related pathways.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating estrogen receptor (ER) binding affinity, selectivity, and downstream signaling mechanisms.
• Metabolic Studies: Employed in preclinical research to explore the effects of modified estradiol analogs on lipid metabolism, bone density, and cardiovascular function.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories using techniques like HPLC and LC-MS.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in medicinal chemistry and steroid pharmacology.

Basic Information

Product Name	18-Nor-17β-Estradiol
CAS No.	15093-14-8
Molecular Formula	C17H24O2
Molecular Weight	260.37 g/mol
Synonyms	18-Norestradiol; 13β-Ethyl-3-hydroxygona-1,3,5(10)-trien-17β-ol; Estra-1,3,5(10)-triene-3,17β-diol, 13-ethyl-; 17β-Hydroxy-13-ethyl-1,3,5(10)-gonatriene-3-ol; 18-Nor-17β-estradiol; 13-Ethyl-3,17β-dihydroxy-1,3,5(10)-estratriene
EINECS	Contact for details

Quality Control

Our 18-Nor-17β-Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include results from advanced techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.