Description

α-Aminoisobutyric Acid Methyl Ester Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of 2-aminoisobutyric acid. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing steric hindrance and conformational constraints into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of non-proteinogenic amino acids and constrained peptides used in drug discovery.
• Peptidomimetics Research: Essential for creating peptide analogs with enhanced metabolic stability and bioavailability by incorporating the sterically hindered 2-aminoisobutyric acid (Aib) residue.
• API Development: Used in the multi-step synthesis of complex target molecules, including potential therapeutics for neurological and metabolic disorders.
• Bioconjugation & Labeling: Serves as a starting material for preparing modified amino acids used in bioconjugation chemistry and probe development.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides that utilize amino acid-based chemistry.
• Academic & Process Chemistry: A valuable reagent for methodological studies in asymmetric synthesis and for scaling up synthetic routes in process chemistry.

Basic Information

Item	Details
Product Name	α-Aminoisobutyric Acid Methyl Ester Hydrochloride
CAS No.	15028-41-8
Molecular Formula	C5H12ClNO2
Molecular Weight	153.61 g/mol
Synonyms	2-Aminoisobutyric Acid Methyl Ester Hydrochloride; Methyl 2-Aminoisobutyrate Hydrochloride; Methyl 2-Amino-2-methylpropanoate Hydrochloride; Aib-OMe·HCl; 2-Methylalanine Methyl Ester Hydrochloride; (RS)-2-Amino-2-methylpropionic Acid Methyl Ester Hydrochloride; DL-2-Aminoisobutyric Acid Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our α-Aminoisobutyric Acid Methyl Ester Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent hydrolysis of the ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.