Description

(S)-(-)-1-Phenylethyl Isocyanate is a high-purity chiral isocyanate building block essential for asymmetric synthesis. This compound matters for its role as a key intermediate in the production of enantiomerically pure pharmaceuticals, agrochemicals, and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and specialty polymer industries for constructing chiral ureas, carbamates, and other derivatives with high stereochemical fidelity.

Application

• As a chiral derivatizing agent for the resolution of racemic alcohols and amines via diastereomeric urea formation.
• Key intermediate in the synthesis of enantiopure pharmaceutical active ingredients, particularly those containing chiral amine or alcohol functionalities.
• Building block for the preparation of chiral stationary phases used in high-performance liquid chromatography (HPLC) for enantiomer separation.
• Monomer for the synthesis of specialty polyurethanes and polymers with tailored optical or mechanical properties.
• Intermediate in agrochemical research for creating chiral pesticides and herbicides.
• Reagent for probing stereoselective reactions and asymmetric catalysis studies.

Basic Information

Product Name	(S)-(-)-1-Phenylethyl Isocyanate
CAS No.	14649-03-7
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(S)-1-Phenylethyl isocyanate; (S)-(-)-α-Methylbenzyl isocyanate; (S)-(-)-1-Phenethyl isocyanate; (S)-(-)-PEIC; (S)-1-Phenylethylisocyanate; (S)-α-Methylbenzyl isocyanate; (S)-(-)-1-Phenylethyl Isothiocyanate (common misnomer); Isocyanic acid, (1S)-1-phenylethyl ester
EINECS	Contact for details

Quality Control

Our (S)-(-)-1-Phenylethyl Isocyanate is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC or GC analysis to confirm enantiomeric excess (typically >98% ee), identity verification by IR and NMR spectroscopy, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and moisture-sensitive nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis and maintain purity. Keep away from strong bases, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0%
Specific Rotation [α]20/D	-80° to -90° (c=1 in toluene)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.