Description

Trifluoroacetyl Isocyanate is a highly reactive and versatile fluorinated building block essential for introducing the trifluoroacetyl moiety into complex molecules. Its primary value lies in enabling the synthesis of compounds with enhanced metabolic stability, lipophilicity, and bioavailability, which are critical attributes in advanced material and pharmaceutical research. This reagent is particularly vital for researchers and process chemists in the agrochemical, pharmaceutical, and specialty chemical industries developing novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of trifluoroacetylated amines, ureas, and carbamates used in drug discovery and development.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Polymer Modification: Serves as a monomer or cross-linking agent for introducing fluorinated segments into polymers, enhancing chemical resistance and surface properties.
• Peptide Chemistry: Employed as a protecting group reagent for amino functions during complex peptide synthesis.
• Ligand and Catalyst Development: Facilitates the creation of novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Used in surface functionalization and the creation of specialty coatings with unique hydrophobic and oleophobic characteristics.

Basic Information

Product Name	Trifluoroacetyl Isocyanate
CAS No.	14565-32-3
Molecular Formula	C3F3NO2
Molecular Weight	139.03 g/mol
Synonyms	2,2,2-Trifluoroacetyl Isocyanate; Trifluoroacetic Isocyanate; TFACI; Isocyanic Acid, Trifluoroacetyl Ester; Perfluoroacetyl Isocyanate; 2,2,2-Trifluoroethanoyl Isocyanate; Trifluoroacetyl Iso-cyanate; CF3C(O)NCO
EINECS	238-618-5

Quality Control

Our Trifluoroacetyl Isocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system supports compliance with relevant global regulatory frameworks for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, store under a dry, inert atmosphere (e.g., nitrogen or argon) in a cool, well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.