Description

Pentafluorophenyl Trifluoroacetate is a highly reactive and versatile fluorinated aryl ester, serving as a critical reagent for the introduction of the pentafluorophenyl group. Its primary value lies in its role as an efficient activating agent and building block in advanced organic synthesis, particularly for peptide coupling and the preparation of active esters. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require high-purity intermediates for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key reagent in peptide synthesis and as an activator for carboxylic acids in amide bond formation.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated active ingredients for crop protection.
• Polymer Chemistry: Acts as a monomer or modifier for introducing fluorinated aromatic units into high-performance polymers and resins.
• Liquid Crystal & OLED Materials: Building block for synthesizing fluorinated aromatic cores used in electronic display materials.
• Proteomics Research: Employed in chemical proteomics for labeling and modifying proteins and peptides.
• Cross-coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Derivatization Agent: Used in analytical chemistry to derivative compounds for enhanced detection via GC or LC-MS.
• Surface Modification: Applied to graft fluorinated aromatic groups onto material surfaces for specific functional properties.

Basic Information

Product Name	Pentafluorophenyl Trifluoroacetate
CAS No.	14533-84-7
Molecular Formula	C8HF8O2
Molecular Weight	272.08 g/mol
Synonyms	Pentafluorophenyl trifluoroacetate; Trifluoroacetic acid pentafluorophenyl ester; Perfluorophenyl trifluoroacetate; 2,3,4,5,6-Pentafluorophenyl trifluoroacetate; PFP-TFA; Pentafluorophenyl ester of trifluoroacetic acid; NSC 5188; C8HF8O2
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl Trifluoroacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA details critical parameters including assay purity, identity confirmation, and impurity profiles, ensuring the material meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its highly volatile nature, keep the container tightly sealed when not in use and store at recommended room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.6 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.