Description

1-Trimethylsilyl-2-Pyrrolidinone is a versatile organosilicon reagent featuring a protected pyrrolidinone moiety. This compound is valued for its role as a silylating agent and a reactive intermediate in advanced organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the silyl-protected pyrrolidinone group.
• Silylation Reagent: Used to protect hydroxyl or amine groups in multi-step synthetic pathways, enhancing selectivity and yield.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Employed in the research and production of specialty polymers and silicon-containing advanced materials.
• Organic Synthesis: A valuable reagent for academic and industrial R&D in constructing heterocyclic compounds and complex organic molecules.

Basic Information

Product Name	1-Trimethylsilyl-2-Pyrrolidinone
CAS No.	14468-90-7
Molecular Formula	C7H15NOSi
Molecular Weight	157.29 g/mol
Synonyms	1-(Trimethylsilyl)-2-pyrrolidinone; N-(Trimethylsilyl)-2-pyrrolidinone; 2-Pyrrolidinone, 1-(trimethylsilyl)-; TMS-Pyrrolidinone; N-Trimethylsilylpyrrolidin-2-one; 1-Trimethylsilylpyrrolidin-2-one; N-TMS-2-Pyrrolidinone
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyl-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can compromise product quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.