Description

Stearic Acid-n-Hydroxysuccinimide Ester is a high-purity, bifunctional chemical linker that enables the stable conjugation of amine-containing molecules to hydrophobic stearic acid chains. This compound is critical for modifying the physicochemical properties of biomolecules, enhancing their stability, bioavailability, and delivery characteristics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing novel drug delivery systems, functional polymers, and diagnostic reagents.

Application

• Bioconjugation Reagent: For the covalent attachment of peptides, proteins, or antibodies to lipophilic carriers to improve pharmacokinetics.
• Lipid Nanoparticle (LNP) Formulation: As a functionalized lipid component for constructing stable, targeted drug delivery vehicles, including for mRNA vaccines and therapeutics.
• Polymer Modification: To introduce long alkyl chains into polymers, enhancing hydrophobicity, self-assembly properties, and membrane compatibility.
• Surface Functionalization: For creating hydrophobic coatings or anchor points on nanoparticles and solid supports for biomedical applications.
• Prodrug Synthesis: Enabling the synthesis of lipophilic prodrugs to increase cellular uptake and controlled release of active pharmaceutical ingredients (APIs).
• Diagnostic Agent Development: In the preparation of contrast agents or fluorescent probes with modified solubility and targeting profiles.

Basic Information

Product Name	Stearic Acid-n-Hydroxysuccinimide Ester
CAS No.	14464-32-5
Molecular Formula	C22H39NO4
Molecular Weight	381.56 g/mol
Synonyms	N-Hydroxysuccinimide Stearate; NHS-Stearate; Stearic Acid N-Hydroxysuccinimide Ester; Octadecanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; N-Stearoyloxysuccinimide; 1-[(Octadecanoyloxy)-2,5-pyrrolidinedione]; N-Succinimidyl Stearate; Stearic Acid Active Ester
EINECS	Contact for details

Quality Control

Our Stearic Acid-n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, THF; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.