Description

n-Succinimidyl Palmitate is a high-purity, activated ester derivative of palmitic acid, widely used as a critical bioconjugation reagent. Its primary value lies in its ability to efficiently introduce a long-chain palmitoyl group into target molecules, such as peptides, proteins, or other amine-containing compounds, under mild aqueous conditions. This product is essential for researchers and manufacturers in the life sciences, pharmaceutical development, and materials science sectors who require reliable and specific fatty acid acylation for applications like protein labeling, lipid modification, and the synthesis of drug conjugates.

Application

• Bioconjugation and Protein Labeling: Used to covalently attach palmitic acid (C16) chains to peptides, proteins, or antibodies for studies on lipidation, membrane anchoring, and protein trafficking.
• Lipidated Peptide Synthesis: A key reagent in solid-phase and solution-phase peptide synthesis for the site-specific incorporation of palmitoyl groups, creating lipopeptides for vaccine and therapeutic development.
• Probe and Diagnostic Agent Development: Facilitates the synthesis of fluorescent or other tagged lipid probes for imaging, cellular uptake studies, and diagnostic assays.
• Polymer and Biomaterial Functionalization: Enables the surface modification of amine-functionalized polymers, nanoparticles, or dendrimers to impart hydrophobic character or specific biological activity.
• Cross-linking and Immobilization: Serves as a homobifunctional cross-linker for amine-amine conjugation or for immobilizing biomolecules onto amine-reactive surfaces.
• Drug Delivery System Fabrication: Utilized in modifying carrier molecules (e.g., PEG, chitosan) to enhance drug loading, stability, and targeted delivery through hydrophobic interactions.

Basic Information

Item	Detail
Product Name	n-Succinimidyl Palmitate
CAS No.	14464-31-4
Molecular Formula	C20H35NO4
Molecular Weight	353.50 g/mol
Synonyms	Palmitic Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimidyl Palmitate; NHS-Palmitate; Palmitoyloxy Succinimide; N-Succinimidyl Hexadecanoate; 16-(2,5-Dioxopyrrolidin-1-yl)oxy-16-oxohexadecanoic acid; Hexadecanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our n-Succinimidyl Palmitate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis and maintain reactivity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	68 - 72 °C
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.