Description

2,5-Dioxopyrrolidin-1-Yl Octanoate is a specialized active ester reagent widely used in organic synthesis and bioconjugation chemistry. This compound matters for its role as a highly efficient acylating agent, enabling the formation of stable amide bonds under mild conditions, which is critical for modifying peptides, proteins, and other amine-containing molecules. It is primarily needed by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in drug discovery, proteomics, and the synthesis of advanced biomaterials.

Application

• Peptide Synthesis: Used as an activated ester for the coupling of amino acids, particularly for introducing caprylic (octanoic) acid moieties.
• Protein Labeling & Bioconjugation: Facilitates the site-specific modification of proteins, antibodies, and enzymes with probes, drugs (ADCs), or polyethylene glycol (PEG) chains.
• Polymer Functionalization: Employed to introduce reactive ester groups onto polymer backbones for subsequent cross-linking or grafting reactions.
• Cross-linking Agent: Acts as a homobifunctional cross-linker for connecting amine-containing biomolecules or materials.
• Intermediate for Prodrugs: Serves as a key building block in the synthesis of prodrugs where controlled release of an active pharmaceutical ingredient is required.
• Surface Modification: Used to create amine-reactive surfaces on chips, beads, or other substrates for biosensor and diagnostic applications.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl Octanoate
CAS No.	14464-30-3
Molecular Formula	C₁₂H₁₉NO₄
Molecular Weight	241.28 g/mol
Synonyms	N-Hydroxysuccinimide Octanoate; NHS-Octanoate; Octanoic Acid N-Hydroxysuccinimide Ester; N-Succinimidyl Octanoate; Caprylic Acid N-Hydroxysuccinimide Ester; 1-[(Octanoyloxy)-2,5-pyrrolidinedione]; NSC 334368; Octanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl Octanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under anhydrous conditions and allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.