Description

1-o-Acetyl-2,3,5-Tri-o-Benzoyl-D-Ribofuranose is a key protected ribofuranose derivative, a critical chiral building block in nucleoside and nucleotide synthesis. Its primary value lies in providing a selectively protected sugar scaffold essential for constructing complex antiviral and anticancer agents. This high-purity intermediate is indispensable for pharmaceutical R&D and production, particularly in the synthesis of modified nucleosides and oligonucleotides.

Application

• Nucleoside Synthesis: A fundamental starting material for the preparation of a wide range of therapeutic nucleoside analogs.
• Antiviral Drug Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) for drugs targeting viruses such as HIV, hepatitis, and herpes.
• Anticancer Agent Development: Serves as a precursor in the creation of nucleoside-based chemotherapeutic agents.
• Oligonucleotide & mRNA Synthesis: Acts as a protected monomer for solid-phase synthesis of oligonucleotides, including those used in mRNA vaccines and therapeutics.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme mechanisms and metabolic pathways involving sugars.
• Process Chemistry & Scale-up: A reliable intermediate for process development and cGMP manufacturing of nucleotide-based pharmaceuticals.

Basic Information

Product Name	1-o-Acetyl-2,3,5-Tri-o-Benzoyl-D-Ribofuranose
CAS No.	14215-97-5
Molecular Formula	C29H24O9
Molecular Weight	516.50 g/mol
Synonyms	1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; 2,3,5-Tri-O-benzoyl-1-O-acetyl-D-ribofuranose; 1-O-Acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose; 1-Acetyl-2,3,5-tribenzoyl-D-ribofuranose; D-Ribofuranose, 1-O-acetyl-2,3,5-tri-O-benzoyl-; 1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranoside; Tribenzoyl acetyl ribofuranose; Acetyl tribenzoyl ribofuranose
EINECS	Contact for details

Quality Control

Our 1-o-Acetyl-2,3,5-Tri-o-Benzoyl-D-Ribofuranose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	-15° to -19° (c=1 in CHCl₃)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.