Description

Trimethylsilyl-D(-)Sorbitol is a high-purity, organosilicon derivative of D-sorbitol, a sugar alcohol. This compound is a valuable chiral auxiliary and derivatizing agent, primarily used to enhance the volatility and detectability of polar compounds in analytical chemistry. It is essential for industries requiring precise stereochemical control and sensitive analytical methods. Key users include pharmaceutical R&D laboratories, fine chemical synthesis facilities, and analytical service providers.

Application

• Chiral Derivatizing Agent for GC/MS: Used to create volatile trimethylsilyl (TMS) ethers of chiral alcohols, sugars, and polyols for enantiomeric separation and analysis by gas chromatography-mass spectrometry.
• Pharmaceutical Intermediate: Serves as a key building block or protecting group in the asymmetric synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Analytical Reference Standard: Employed as a high-purity standard for method development and validation in quality control laboratories for carbohydrate and polyol analysis.
• Stereochemistry Studies: Utilized in academic and industrial research to determine enantiomeric purity and absolute configuration of chiral molecules.
• Fine Chemical Synthesis: Acts as a reagent in the preparation of specialty siloxanes and other organosilicon compounds with specific stereochemical properties.

Basic Information

Product Name	Trimethylsilyl-D(-)Sorbitol
CAS No.	14199-80-5
Molecular Formula	C15H38O6Si5
Molecular Weight	483.88 g/mol
Synonyms	D-Sorbitol, pentakis(trimethylsilyl) ether; 1,2,3,4,5,6-Hexanepentol, 1,2,3,4,5,6-pentakis-O-(trimethylsilyl)-, (1S,2R,3R,4R,5R)-; Pentakis(trimethylsilyl) D-sorbitol; TMS-D-Sorbitol; D-(-)-Sorbitol pentatrimethylsilyl ether; (1S,2R,3R,4R,5R)-1,2,3,4,5,6-Pentakis-O-(trimethylsilyl)hexane-1,2,3,4,5,6-hexol
EINECS	Contact for details

Quality Control

Our Trimethylsilyl-D(-)Sorbitol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent testing. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), please contact our technical team.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral GC/HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.