Description

(2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-2,3,5,6,7,7A-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is a high-purity, stereochemically defined organic compound that serves as a critical chiral building block and intermediate in advanced chemical synthesis. Its complex molecular architecture, featuring fused pyrrolizidine and dihydroxy acid ester moieties, makes it invaluable for constructing sophisticated pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who require precise stereochemical control for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological or anti-infective pathways.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where specific stereochemistry is crucial for biological activity and environmental safety.
• Asymmetric Catalysis: Employed as a precursor or ligand in catalytic systems for stereoselective chemical transformations.
• Natural Product Synthesis: A valuable building block for the total synthesis of complex natural products containing pyrrolizidine alkaloid structures.
• Biochemical Research: Utilized in studies exploring enzyme inhibitors or receptor ligands due to its specific three-dimensional conformation.
• Fine Chemical Production: Serves as a high-value intermediate for custom synthesis and contract manufacturing organizations (CMOs).

Basic Information

Product Name	(2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-2,3,5,6,7,7A-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester
CAS No.	14140-18-2
Molecular Formula	C15H25NO4
Molecular Weight	283.37 g/mol
Synonyms	2,3-Dihydroxy-2-isopropylbutanoic acid (1R,7aS)-2,3,5,6,7,7a-hexahydro-1H-pyrrolizin-1-ylmethyl ester; (1R,7aS)-Hexahydro-1H-pyrrolizin-1-ylmethyl (2S,3R)-2,3-dihydroxy-2-(1-methylethyl)butanoate; L-Hyoscyamine acid ester derivative; Tropane alkaloid intermediate; Pyrrolizidine ester; Chiral dihydroxy acid ester
EINECS	Contact for details

Quality Control

Our (2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoic Acid [(1R,7As)-2,3,5,6,7,7A-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess and stereochemical purity, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.