Description

Semustine is a nitrosourea-based alkylating agent with significant research and pharmaceutical applications. This compound is valued for its potent biological activity, making it a critical material in advanced oncology research and development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for investigative and therapeutic purposes.

Application

• Oncology Research & Drug Development: A key investigational compound in the study of alkylating agents and their mechanisms of action against various cancer cell lines.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex therapeutic agents and specialized pharmaceutical formulations.
• Biochemical Research: Used in laboratory studies to understand DNA alkylation, cross-linking, and the cellular response to chemotherapeutic stress.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development, validation, and impurity profiling.
• Preclinical Studies: Utilized in animal model research to evaluate pharmacokinetics, efficacy, and toxicity profiles.

Basic Information

Product Name	Semustine
CAS No.	13909-09-6
Molecular Formula	C9H18ClN3O2
Molecular Weight	247.71 g/mol
Synonyms	Methyl-CCNU; Methyl Lomustine; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; 4-Methylcyclohexylchloroethylnitrosourea; NSC 95441; CCRIS 1631; 1-Nitrosourea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-; UNII-4M862E1QFA
EINECS	Contact for details

Quality Control

Our Semustine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles for API intermediates where applicable.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being strictly light-sensitive and easily oxidized, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (typically 15-25°C) or as specified on the label. Keep the container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.