Description

1,1'-(2,3,5,6-Tetramethyl-p-Phenylene)Bis[3-(2-Chloroethyl)-3-Nitrosourea] is a specialized, high-potency alkylating agent belonging to the nitrosourea class of compounds. This compound is critical for advanced research and development in oncology and targeted drug discovery due to its bifunctional DNA cross-linking mechanism. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers developing next-generation chemotherapeutic agents and studying DNA alkylation processes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel anticancer drugs and experimental chemotherapeutic agents.
• Biomedical Research: Used as a potent alkylating agent in biochemical and molecular biology studies to investigate DNA damage, repair mechanisms, and cell cycle arrest.
• Oncology Drug Discovery: A critical reagent in preclinical research for developing targeted therapies, particularly for brain tumors and other resistant cancers where nitrosoureas show activity.
• Chemical Biology Tool: Employed to study structure-activity relationships (SAR) of bifunctional alkylating agents and their interactions with biological macromolecules.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	1,1'-(2,3,5,6-Tetramethyl-p-Phenylene)Bis[3-(2-Chloroethyl)-3-Nitrosourea]
CAS No.	13907-60-3
Molecular Formula	C18H24Cl2N6O4
Molecular Weight	459.33 g/mol
Synonyms	1,1'-(2,3,5,6-Tetramethyl-1,4-phenylene)bis[3-(2-chloroethyl)-1-nitrosourea]; TMCNU; NSC 178248; Tetramethylphenylene bis(chloroethyl nitrosourea); 1,4-Bis[3-(2-chloroethyl)-3-nitrosoureido]-2,3,5,6-tetramethylbenzene; p-Xylylene bis(chloroethyl nitrosourea); Bifunctional nitrosourea derivative
EINECS	Contact for details

Quality Control

Our 1,1'-(2,3,5,6-Tetramethyl-p-Phenylene)Bis[3-(2-Chloroethyl)-3-Nitrosourea] is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and thermal degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Store separately from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.