Description

Ethyl (S)-2-Amino-2-Methylbutyrate is a high-purity, non-proteinogenic amino acid ester derivative. This chiral building block is critical for the synthesis of complex molecules where stereochemical integrity is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptidomimetics and protease inhibitors.
• Asymmetric Synthesis: Serves as a versatile precursor for introducing the (S)-2-amino-2-methylbutyric acid moiety in catalytic asymmetric reactions.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a sterically hindered, non-natural amino acid residue.
• Biochemical Research: Employed in the study of enzyme mechanisms and as a substrate analog in metabolic pathway investigations.
• Agrochemical Development: Potential intermediate for creating chiral herbicides or plant growth regulators with specific activity.
• Ligand Synthesis: Building block for constructing chiral ligands used in metal-catalyzed transformations.

Basic Information

Product Name	Ethyl (S)-2-Amino-2-Methylbutyrate
CAS No.	13893-46-4
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(S)-2-Amino-2-methylbutyric acid ethyl ester; L-2-Amino-2-methylbutyric acid ethyl ester; Ethyl L-2-amino-2-methylbutyrate; Ethyl (S)-2-amino-2-methylbutanoate; (S)-2-Methyl-2-aminobutanoic acid ethyl ester; (S)-α-Methyl-α-aminobutyric acid ethyl ester; AAMB-OEt
EINECS	Contact for details

Quality Control

Our Ethyl (S)-2-Amino-2-Methylbutyrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep container tightly sealed under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.