Description

4-Fluoro-4'-Methylchalcone is a high-purity fluorinated chalcone derivative, a key structural motif in organic synthesis and pharmaceutical research. This compound matters as a versatile and valuable building block for developing novel bioactive molecules, particularly due to the strategic introduction of fluorine and methyl groups which can significantly alter physicochemical and biological properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, material science, and as a reference standard.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly for anti-inflammatory, anticancer, and antimicrobial agents.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and metabolic stability of lead compounds.
• Agrochemical Development: Employed in the research and synthesis of new pesticides and herbicides, leveraging the bioactivity of the chalcone core.
• Organic Synthesis Building Block: A versatile intermediate for constructing more complex heterocyclic systems like flavones, pyrazolines, and other fused-ring structures.
• Material Science Research: Investigated for its potential in creating organic semiconductors, non-linear optical (NLO) materials, and fluorescent probes due to its conjugated π-system.
• Biochemical Tool Compound: Used in biochemical assays to study enzyme inhibition, particularly targeting kinases and other disease-relevant proteins.

Basic Information

Product Name	4-Fluoro-4'-Methylchalcone
CAS No.	13565-38-3
Molecular Formula	C₁₇H₁₅FO
Molecular Weight	254.30 g/mol
Synonyms	1-(4-Fluorophenyl)-3-(4-methylphenyl)-2-propen-1-one; (E)-1-(4-Fluorophenyl)-3-(p-tolyl)prop-2-en-1-one; 4-Fluoro-4'-methylchalcone; 4'-Methyl-4-fluorochalcone; p-Fluorophenyl p-tolyl ketone ethylene; FMC; Chalcone, 4-fluoro-4'-methyl-; (E)-3-(4-Methylphenyl)-1-(4-fluorophenyl)prop-2-en-1-one
EINECS	Contact for details

Quality Control

Our 4-Fluoro-4'-Methylchalcone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.