Description

n-Des(5-Methylpyrazinecarbonyl)-n-Ethylcarboxyl Glipizide is a key pharmaceutical intermediate and a structural analog of the widely used antidiabetic drug Glipizide. This compound is of significant value in research and development for the synthesis of novel sulfonylurea derivatives and for metabolic studies. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on diabetes treatment, drug discovery, and analytical method development.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Glipizide and its structural analogs for diabetes medication.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new sulfonylurea-based therapeutics.
• Metabolite Studies: Serves as a reference standard or metabolite in pharmacokinetic and pharmacodynamic research related to Glipizide.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, or other chromatographic methods.
• Process Chemistry: Used in scaling up and optimizing manufacturing processes for antidiabetic active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-Des(5-Methylpyrazinecarbonyl)-n-Ethylcarboxyl Glipizide
CAS No.	13554-93-3
Molecular Formula	C21H27N5O4S
Molecular Weight	445.54 g/mol
Synonyms	1-Cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea; Desmethylpyrazine Glipizide; Glipizide Impurity; Glipizide Related Compound; N-Des(5-Methylpyrazinecarbonyl) Glipizide; 5-Methyl-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]pyrazinecarboxamide; N1-(4-[N'-(Cyclohexylcarbamoyl)sulfamoyl]phenethyl)-5-methylpyrazine-2-carboxamide
EINECS	Contact for details

Quality Control

Our n-Des(5-Methylpyrazinecarbonyl)-n-Ethylcarboxyl Glipizide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; ensure the container is sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.