Description

Hydroxocobalamin Hydrochloride is a chemically stable, injectable form of vitamin B12, essential for critical biological functions. This high-purity compound is vital for addressing severe B12 deficiencies and cyanide poisoning, offering superior stability and safety profiles compared to other cobalamin salts. It is a key active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical, nutraceutical, and advanced research sectors requiring a reliable and efficacious source of vitamin B12.

Application

• Pharmaceutical Formulations: Primary API in injectable solutions and lyophilized powders for the treatment of vitamin B12 deficiency and pernicious anemia.
• Antidote Production: Critical component in emergency kits and pharmaceutical preparations used as an antidote for acute cyanide poisoning.
• Nutraceutical & Dietary Supplements: Used in high-end supplement formulations, particularly those targeting advanced bioavailability and metabolic support.
• Biochemical Research: Essential reagent in cell culture media, enzymatic studies, and metabolic pathway research involving cobalamin-dependent processes.
• Veterinary Medicine: Incorporated into injectable vitamins and therapeutic treatments for livestock and companion animals.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Hydroxocobalamin Hydrochloride
CAS No.	13422-52-1
Molecular Formula	C62H90ClCoN13O15P
Molecular Weight	1382.73 g/mol
Synonyms	Vitamin B12a Hydrochloride; Hydroxocobalamin HCl; α-(5,6-Dimethylbenzimidazolyl)hydroxocobamide Hydrochloride; Hydroxocobalamin Chloride; Cobalamin Hydroxide Monohydrochloride; Hydroxocobalamin (Hydrochloride); Aquocobalamin Hydrochloride; Vitamin B12 Hydroxide Hydrochloride
EINECS	236-533-5

Quality Control

Our Hydroxocobalamin Hydrochloride is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing purity, identity, and impurity profiles to ensure compliance and traceability for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	Dark red crystalline powder or crystals
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0 %
pH (1% Solution)	4.0 - 6.0
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.