Description

(4R)-1-Methyl-4-Propyl-L-Proline Methyl Ester is a high-purity, non-natural proline derivative that serves as a critical chiral building block in advanced organic synthesis. Its defined stereochemistry and functionalized pyrrolidine ring make it a valuable intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is primarily utilized by pharmaceutical and biotechnology R&D teams for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting enzymatic pathways.
• Protease Inhibitor Development: Used in research and production of inhibitors for various proteases due to its proline-based scaffold.
• Peptidomimetics & Constrained Peptides: Serves as a backbone-constrained amino acid analog for designing stable, bioactive peptide mimics.
• Asymmetric Catalysis Ligand Precursor: A potential precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Academic & Industrial Research: Used in methodological development and the synthesis of novel chemical entities for biological evaluation.

Basic Information

Product Name	(4R)-1-Methyl-4-Propyl-L-Proline Methyl Ester
CAS No.	13380-39-7
Molecular Formula	C10H19NO2
Molecular Weight	185.26 g/mol
Synonyms	L-Proline, 1-methyl-4-propyl-, methyl ester, (4R)-; Methyl (4R)-1-methyl-4-propyl-L-prolinate; (4R)-1-Methyl-4-propyl-L-proline methyl ester; (2S,4R)-1-Methyl-4-propylpyrrolidine-2-carboxylic acid methyl ester; 1-Methyl-4-propyl-L-proline methyl ester; (4R)-1-Methyl-4-propylproline methyl ester; Methyl 1-methyl-4-propyl-L-prolinate
EINECS	Contact for details

Quality Control

Our (4R)-1-Methyl-4-Propyl-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.