Description

Spiro[8-Azabicyclo[3.2.1]Octane-3,2'-[1,3]Dioxolane] (CAS NO 13375-57-0) is a sophisticated spirocyclic organic compound featuring a fused azabicyclooctane and dioxolane ring system. This unique molecular architecture makes it a highly valuable intermediate for the synthesis of complex pharmacologically active molecules, particularly in the development of central nervous system (CNS) agents and other fine chemicals. It is primarily sought after by pharmaceutical R&D teams and advanced fine chemical manufacturers requiring precise, high-purity building blocks for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of tropane alkaloid derivatives and other bioactive compounds targeting the central nervous system.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, especially those requiring a rigid, three-dimensional spirocyclic scaffold.
• Asymmetric Synthesis: Serves as a precursor or template for creating chiral molecules in stereoselective synthesis, crucial for producing single-enantiomer pharmaceuticals.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials that benefit from its complex bicyclic structure.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling in related pharmaceutical processes.

Basic Information

Product Name	Spiro[8-Azabicyclo[3.2.1]Octane-3,2'-[1,3]Dioxolane]
CAS No.	13375-57-0
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	8-Azabicyclo[3.2.1]octane-3-spiro-2'-(1',3'-dioxolane); 3-Spiro(1,3-dioxolan-2-yl)-8-azabicyclo[3.2.1]octane; 8-Azabicyclo[3.2.1]octane, 3-spiro-2'-(1',3'-dioxolane); Tropane-3-spiro-2'-(1',3'-dioxolane); 3-(1,3-Dioxolan-2-yl)-8-azabicyclo[3.2.1]octane; 8-Methyl-8-azabicyclo[3.2.1]octane-3-spiro-2'-(1',3'-dioxolane) (common misnomer); Tropane-3-spiro-2'-dioxolane
EINECS	Contact for details

Quality Control

Our Spiro[8-Azabicyclo[3.2.1]Octane-3,2'-[1,3]Dioxolane] is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and acids. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.