Description

4-(Trimethylsilyl)Morpholine is a versatile organosilicon reagent featuring a morpholine ring protected by a trimethylsilyl (TMS) group. This compound is highly valued in synthetic organic chemistry as a protected amine precursor and a silylating agent, enabling critical transformations in complex molecule assembly. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for sensitive synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where a protected secondary amine functionality is required.
• Silylating Agent: Used to introduce the trimethylsilyl group onto nucleophiles like alcohols, amines, and thiols, protecting them during multi-step synthesis.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents.
• Polymer & Material Science: Monomer or modifier in the creation of specialty silicones and silicon-containing polymers.
• Chemical Research & Development: A valuable reagent for method development and the synthesis of novel chemical entities in academic and industrial R&D labs.
• Ligand & Catalyst Preparation: Used to synthesize nitrogen-containing ligands for metal complexes used in catalysis.

Basic Information

Product Name	4-(Trimethylsilyl)Morpholine
CAS No.	13368-42-8
Molecular Formula	C7H17NOSi
Molecular Weight	159.30 g/mol
Synonyms	N-(Trimethylsilyl)morpholine; Morpholine, 4-(trimethylsilyl)-; TMS-Morpholine; 4-Trimethylsilylmorpholine; N-Trimethylsilylmorpholine; 4-(Trimethylsilyl)-morpholine; Morpholine, N-(trimethylsilyl)-; 4-(Trimethylsilyl)morpholine
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)Morpholine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat and ignition sources. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.