Description

T-Butyl-p-Nitrophenyl Carbonate is a specialized organic carbonate ester, widely recognized as a versatile reagent in synthetic organic chemistry. Its primary value lies in its role as a robust protecting and activating agent, particularly for the introduction of the tert-butoxycarbonyl (Boc) protecting group onto amines and other nucleophiles. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, where it facilitates the synthesis of peptides, active pharmaceutical ingredients (APIs), and complex organic intermediates under controlled conditions.

Application

• Boc-Protection Reagent: Selective protection of primary and secondary amines in peptide and alkaloid synthesis.
• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Used in the synthesis of specialized polymers and functional materials requiring protected amine groups.
• Bioconjugation: Facilitates the controlled modification of biomolecules for research and diagnostic applications.
• Chemical Research & Development: A valuable tool for medicinal chemists and process development scientists exploring new synthetic pathways.
• Fine Chemical Production: Employed in the manufacture of high-value, low-volume specialty chemicals and catalysts.

Basic Information

Product Name	T-Butyl-p-Nitrophenyl Carbonate
CAS No.	13303-10-1
Molecular Formula	C11H13NO5
Molecular Weight	239.23 g/mol
Synonyms	tert-Butyl 4-nitrophenyl carbonate; 4-Nitrophenyl tert-butyl carbonate; p-Nitrophenyl tert-butyl carbonate; Boc-ON; (4-Nitrophenyl) tert-butyl carbonate; tert-Butoxycarbonyl 4-nitrophenyl ester; 1-(tert-Butoxycarbonyloxy)-4-nitrobenzene; BOC-ON reagent
EINECS	Contact for details

Quality Control

Our T-Butyl-p-Nitrophenyl Carbonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and production applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.