Description

R-(+)-Hyoscyamine is the pharmacologically active enantiomer of hyoscyamine, a tropane alkaloid derived from plants of the Solanaceae family. This high-purity chiral compound is critical for research and development in pharmaceutical synthesis and advanced medicinal chemistry. It serves as a vital intermediate and reference standard for manufacturers and research institutions focused on anticholinergic agents, analytical method development, and enantioselective synthesis.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key chiral building block for the production of antispasmodic and antisecretory medications.
• Reference Standard in Analytical Chemistry: Used for method validation, calibration, and quality control in HPLC, GC, and LC-MS assays for pharmaceutical products.
• Biochemical Research: Tool compound for studying muscarinic acetylcholine receptor (mAChR) interactions and anticholinergic pathways.
• Enantioselective Synthesis Studies: Serves as a model compound in developing and optimizing chiral separation techniques and asymmetric synthesis routes.
• Formulation Development: Used in R&D for developing controlled-release formulations and combination drug products.

Basic Information

Product Name	R-(+)-Hyoscyamine
CAS No.	13269-35-7
Molecular Formula	C17H23NO3
Molecular Weight	289.37 g/mol
Synonyms	(+)-Hyoscyamine; D-Hyoscyamine; (3S)-Tropanyl (2S)-3-hydroxy-2-phenylpropanoate; Atropine (-)-Isomer; Levsin (as the sulfate salt); Anaspaz; Cystospaz; Donnamar; Egazil; Hyo-Pak; Hyosol; Hyospaz; IB-Stat; Levbid; Levsinex; Medispaz; NuLev; Oscimin; Pasmex; Symax
EINECS	Contact for details

Quality Control

Our R-(+)-Hyoscyamine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, potency, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Specific Rotation	+20° to +23° (c=1 in H2O)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.