Description

(1As)-1,5-Dimethyl-6-Methoxy-8β-(Carbamoyloxymethyl)-8Aα-Hydroxy-1,1Aα,2,8,8A,8Bα-Hexahydroazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione is a complex heterocyclic compound featuring a unique azirino-pyrrolo-indole tricyclic core structure. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated synthetic intermediate or a potential pharmacophore. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and the exploration of new therapeutic agents. The presence of multiple functional groups, including the carbamoyloxymethyl moiety, makes it a versatile building block for targeted chemical modifications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially in oncology and neurological disorder research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new compounds with potential biological activity.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition or receptor binding mechanisms due to its intricate structure.
• Academic & Institutional R&D: Utilized in university and government laboratories for fundamental research in organic synthesis and heterocyclic chemistry.
• Contract Research Organization (CRO) Projects: Supplied to CROs for client-specific custom synthesis and process development work.
• High-Purity Reference Standard: Can be supplied as a characterized standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(1As)-1,5-Dimethyl-6-Methoxy-8β-(Carbamoyloxymethyl)-8Aα-Hydroxy-1,1Aα,2,8,8A,8Bα-Hexahydroazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione
CAS No.	13164-90-4
Molecular Formula	C19H23N3O6
Molecular Weight	389.41 g/mol
Synonyms	1,5-Dimethyl-6-methoxy-8β-(carbamoyloxymethyl)-8aα-hydroxy-1,1aα,2,8,8a,8bα-hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Azirinomycin derivative; Mitomycin C analogue; Pyrroloindole dione derivative; 8β-(Aminocarbonyloxy)methyl derivative; Hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 1,5-dimethyl-6-methoxy-8β-[(aminocarbonyloxy)methyl]-8aα-hydroxy-1,1aα,2,8,8a,8bα-hexahydro-, (1aS,8S,8aR,8bR)-; (1aS,8S,8aR,8bR)-1,5-Dimethyl-6-methoxy-8β-[(aminocarbonyloxy)methyl]-8aα-hydroxy-1,1aα,2,8,8a,8bα-hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
EINECS	Contact for details

Quality Control

Our (1As)-1,5-Dimethyl-6-Methoxy-8β-(Carbamoyloxymethyl)-8Aα-Hydroxy-1,1Aα,2,8,8A,8Bα-Hexahydroazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity, well-characterized advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound may be light-sensitive and/or hygroscopic; handle and store under an inert atmosphere if specified for your grade. Keep container tightly sealed in a dry, well-ventilated place. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Standard Grade) ≥ 98.0% (High Purity Grade)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.