Description

Triisopropylsilyl Chloride is a highly reactive organosilicon compound, widely recognized as a premier protecting group reagent in synthetic organic chemistry. Its primary value lies in its exceptional steric bulk and selectivity, which allows for the efficient protection of hydroxyl groups under mild conditions, a critical step in complex multi-step syntheses. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective protection of alcohol functionalities during the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of advanced pesticides and herbicides, where it aids in building specific molecular architectures.
• Peptide & Oligonucleotide Chemistry: Employed to protect sensitive hydroxyl groups on nucleosides, sugars, and amino acid side chains, preventing unwanted side reactions.
• Material Science & Polymer Chemistry: Serves as a precursor or surface-modifying agent for creating specialized silicon-based polymers and functionalized surfaces.
• Natural Product Synthesis: Indispensable in the total synthesis of complex natural products like macrolides and polyketides, where orthogonal protection strategies are required.
• Process Chemistry & Scale-up: Valued for its robustness and predictability, making it suitable for transitioning from laboratory-scale research to industrial manufacturing.

Basic Information

Product Name	Triisopropylsilyl Chloride
CAS No.	13154-24-0
Molecular Formula	C9H21ClSi
Molecular Weight	192.80 g/mol
Synonyms	Chlorotriisopropylsilane; TIPS-Cl; Triisopropylchlorosilane; Triisopropylsilylchloride; 1-Chlorotriisopropylsilane; Silane, chlorotriisopropyl-; NSC 163082; Tri-iso-propylsilyl chloride
EINECS	236-107-7

Quality Control

Every batch of Triisopropylsilyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles to ensure the material meets the exacting standards required for research and cGMP manufacturing. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and handle in a controlled environment to prevent moisture absorption and ensure product integrity. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.