Description

3-Hydroxybromazepam is a key pharmaceutical intermediate and metabolite of the benzodiazepine class. This compound is critical for research and development in medicinal chemistry, particularly for metabolic studies and analytical reference standards. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development, quality control, and forensic analysis.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and research of active pharmaceutical ingredients (APIs) within the benzodiazepine family.
• Analytical Reference Standard: Used for qualitative and quantitative analysis in High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Mass Spectrometry (MS) methods.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolic pathways and biological activity of bromazepam and related compounds.
• Forensic and Clinical Toxicology: Serves as a certified reference material for the accurate identification and quantification of substances in forensic investigations and clinical testing.
• Impurity Profiling: Employed as a known impurity standard to monitor and control the quality of bromazepam API during manufacturing, ensuring compliance with ICH guidelines.
• Biochemical Research: Used in studies investigating the mechanism of action and receptor binding affinity of benzodiazepines.

Basic Information

Product Name	3-Hydroxybromazepam
CAS No.	13132-73-5
Molecular Formula	C₁₄H₁₀BrN₃O₂
Molecular Weight	332.15 g/mol
Synonyms	7-Bromo-5-(2-pyridyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-OH-Bromazepam; Bromazepam 3-Hydroxy Metabolite; 3-Hydroxy-7-bromo-5-(pyridin-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-Hydroxy Brz; Ro 05-3590/001
EINECS	Contact for details

Quality Control

Our 3-Hydroxybromazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced chromatographic techniques (HPLC, GC). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.