Description

L-Glutamic Acid α-Benzyl Ester is a protected amino acid derivative of significant importance in synthetic organic and peptide chemistry. This compound serves as a crucial chiral building block, enabling the controlled synthesis of complex peptides and pharmaceutical intermediates. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the production of bioactive peptides, prodrugs, and specialized organic molecules.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis, where the benzyl ester protects the α-carboxyl group of glutamic acid.
• Pharmaceutical Intermediates: Used in the research and development of novel drug candidates, particularly those targeting neurological and metabolic pathways.
• Bioconjugation & Prodrug Design: Facilitates the creation of peptide-drug conjugates and prodrugs designed for targeted delivery and controlled release.
• Biochemical Research: Employed in studies of enzyme mechanisms, receptor-ligand interactions, and as a standard in analytical method development.
• Fine Chemical Production: Acts as a chiral synthon for the manufacture of non-peptidic compounds requiring a glutamic acid backbone with a protected carboxylic acid function.

Basic Information

Product Name	L-Glutamic Acid α-Benzyl Ester
CAS No.	13030-09-6
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	H-Glu(OBzl)-OH; L-Glutamic Acid 1-Benzyl Ester; (S)-2-Aminopentanedioic Acid 1-Benzyl Ester; Benzyl L-Glutamate; Glutamic Acid Benzyl Ester; α-Benzyl L-Glutamate; (S)-5-Benzyloxy-5-oxopentan-2-aminium
EINECS	235-889-1

Quality Control

Our L-Glutamic Acid α-Benzyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-18.0° to -22.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.