Description

Lomustine CAS NO 13010-47-4 is a potent alkylating nitrosourea compound used as an antineoplastic agent. Its primary value lies in its ability to cross the blood-brain barrier, making it a critical therapeutic option for specific central nervous system malignancies. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing and producing chemotherapy treatments for brain tumors and other cancers.

Application

• Oncological Pharmaceutical Manufacturing: As a key active pharmaceutical ingredient (API) in the formulation of chemotherapy drugs for the treatment of brain tumors, including glioblastoma multiforme and medulloblastoma.
• Hodgkin's Lymphoma Treatment: Used as a secondary-line therapy in combination chemotherapy regimens for Hodgkin's lymphoma.
• Clinical Research & Development: Serves as a reference standard and a critical component in preclinical and clinical studies investigating new cancer therapies and drug delivery mechanisms.
• Pharmaceutical Compounding: Utilized in specialized pharmacy settings for the preparation of patient-specific chemotherapeutic doses.
• Biomedical Research: Employed in laboratory studies to investigate mechanisms of alkylating agent activity, DNA cross-linking, and cellular apoptosis in cancer models.

Basic Information

Product Name	Lomustine
CAS No.	13010-47-4
Molecular Formula	C9H16ClN3O2
Molecular Weight	233.70 g/mol
Synonyms	CCNU; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea; Belustine; Cecenu; Gleostine; Lomustin; Chloroethylcyclohexylnitrosourea
EINECS	235-861-2

Quality Control

Our Lomustine is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and related substances tests. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability, consistency, and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.