Description

L-Tyrosine Tert Butyl Ester is a protected amino acid derivative, specifically the tert-butyl ester of the essential amino acid L-Tyrosine. This compound is a crucial building block (synthon) in organic synthesis, particularly for the preparation of peptides and complex molecules where the protection of the carboxylic acid group is required. It is primarily utilized by pharmaceutical research and development teams, as well as by fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and biochemical tools.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for constructing peptide chains.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of more complex drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in the development of enzyme inhibitors, receptor ligands, and other bioactive compounds for research purposes.
• Fine Chemical Production: Employed in custom synthesis and the manufacture of specialized organic compounds for various high-value applications.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection that can be selectively removed under mild acidic conditions, facilitating complex multi-step syntheses.

Basic Information

Product Name	L-Tyrosine Tert Butyl Ester
CAS No.	11674-12-7
Molecular Formula	C₁₃H₁₉NO₃
Molecular Weight	237.29 g/mol
Synonyms	L-Tyrosine tert-butyl ester; H-Tyr-OtBu; (S)-2-Amino-3-(4-hydroxyphenyl)propanoic acid tert-butyl ester; tert-Butyl L-tyrosinate; Tyrosine tert-butyl ester; Boc-Tyr-OH (Note: Often confused, but Boc-Tyr-OH is the Boc-protected variant); 4-Hydroxy-L-phenylalanine tert-butyl ester; L-Tyrosine, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

We supply L-Tyrosine Tert Butyl Ester in high-purity grades suitable for research and pharmaceutical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards, including identity confirmation, purity analysis, and impurity profiling. Certificates of Analysis (COA) are available upon request, detailing batch-specific results from analytical methods such as HPLC, NMR, and optical rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (Optical Rotation)	[α]²⁰D = Specific range provided on COA
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥98.5%
Optical Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.