Description

2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone is a key protected ribose derivative, serving as a crucial chiral building block and synthetic intermediate in advanced organic synthesis. Its primary value lies in providing a versatile, silyl-protected scaffold for the controlled construction of nucleoside analogs, carbohydrate-based pharmaceuticals, and other complex bioactive molecules. This high-purity intermediate is essential for research and production in pharmaceutical development, particularly for antiviral and anticancer agents, as well as in specialized fine chemical and process chemistry applications where precise stereochemistry is required.

Application

• Nucleoside & Nucleotide Analog Synthesis: A critical precursor for constructing modified sugar moieties in potential antiviral (e.g., hepatitis, HIV) and anticancer drug candidates.
• Carbohydrate Chemistry & Glycobiology: Used in the synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics for therapeutic and diagnostic research.
• Pharmaceutical Intermediate: Serves as a chiral building block in multi-step syntheses of active pharmaceutical ingredients (APIs) requiring high stereochemical fidelity.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of specialty fine chemicals.
• Protecting Group Strategy: The tris(trimethylsilyl) protection allows for selective deprotection and further functionalization at specific hydroxyl positions.
• Bioconjugation & Probe Development: Useful for creating labeled carbohydrate probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone
CAS No.	10589-34-1
Molecular Formula	C14H32O5Si3
Molecular Weight	364.66 g/mol
Synonyms	D-Ribono-1,4-lactone, 2,3,5-tris-O-(trimethylsilyl)-; 2,3,5-Tri-O-trimethylsilyl-D-ribono-1,4-lactone; Tris(trimethylsilyl) D-ribonolactone; 2,3,5-Tris-O-(trimethylsilyl)-D-ribono-γ-lactone; TMS-protected D-ribonolactone; D-Ribono-γ-lactone, 2,3,5-tris(trimethylsilyl) ether; 10589-34-1; 2,3,5-Tri-O-TMS-D-ribono-1,4-lactone
EINECS	Contact for details

Quality Control

Our 2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Ribonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for use as a pharmaceutical intermediate. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.