Description

Ent-17α-Ethynylestra-1,3,5(10)-trien-3,17-diol is a high-purity synthetic steroid derivative, specifically the enantiomer of the well-known pharmaceutical intermediate 17α-ethynylestradiol. This compound is valued for its precise stereochemistry and serves as a critical chiral building block in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel steroid-based therapeutics, hormone receptor modulators, and for analytical reference standards.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Hormone Receptor Research: Used as a reference compound or a starting material in studies targeting estrogen and other steroid hormone receptors.
• Chemical Synthesis: Serves as a specialized building block for creating enantiomerically pure steroid analogs for structure-activity relationship (SAR) studies.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) in analytical laboratories for method development, validation, and quality control (HPLC, GC-MS).
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in organic chemistry, medicinal chemistry, and endocrinology.

Basic Information

Product Name	Ent-17α-Ethynylestra-1,3,5(10)-trien-3,17-diol
CAS No.	10453-39-1
Molecular Formula	C20H24O2
Molecular Weight	296.40 g/mol
Synonyms	Ent-17α-Ethynylestradiol; (8R,9S,13S,14S,17R)-17-Ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol; 17α-Ethynylestra-1,3,5(10)-triene-3,17β-diol enantiomer; Enantiomer of EE2; 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol (ent-)
EINECS	Contact for details

Quality Control

Our Ent-17α-Ethynylestra-1,3,5(10)-trien-3,17-diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.