Description

Protac Linker 32 is a specialized bifunctional chemical linker, a critical component in the design and synthesis of Proteolysis-Targeting Chimeras (PROTACs). Its molecular structure enables the precise connection of a target protein-binding warhead to an E3 ubiquitin ligase recruiter, facilitating the targeted degradation of disease-causing proteins. This compound is essential for researchers and developers in pharmaceutical R&D and biotechnology focused on novel therapeutic modalities.

Application

• PROTAC Molecule Synthesis: Core building block for constructing heterobifunctional degraders targeting a wide range of proteins.
• Cancer Research: Development of targeted protein degradation therapies for oncology, including challenging undruggable targets.
• Neurological Disease Models: Used in research for neurodegenerative conditions like Alzheimer's and Parkinson's disease.
• Inflammatory & Autoimmune Research: Facilitating the degradation of key inflammatory mediators and signaling proteins.
• Chemical Biology Tool Development: Creating molecular probes to study protein function and validate new drug targets via degradation.
• Preclinical Drug Development: A key intermediate in the lead optimization and candidate selection stages for novel degrader therapeutics.

Basic Information

Product Name	Protac Linker 32
CAS No.	10436-21-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker 32; 1,4-Bis(3-aminopropoxy)butane; 1,4-Butanediol bis(3-aminopropyl) ether; 3,3'-(Butane-1,4-diylbis(oxy))dipropan-1-amine; 1,4-Bis(3-aminopropoxy)butane; Bis(3-aminopropyl) ether of 1,4-butanediol; 1,4-Bis(3-aminopropyloxy)butane
EINECS	Contact for details

Quality Control

Our Protac Linker 32 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive PROTAC assembly. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and scale-up with material produced under GMP-like conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.