Description

3α,17α-Bis(Trimethylsilyloxy)-5α-Androstane is a key steroidal intermediate, specifically a silyl-protected derivative of 5α-androstane. This compound is of significant value in synthetic organic chemistry for the protection of hydroxyl groups, enabling complex multi-step syntheses. It is primarily required by research institutions and pharmaceutical manufacturers developing novel steroid-based therapeutics and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of steroidal drugs, including hormone therapies and anti-inflammatory agents.
• Organic Synthesis Reagent: Used as a protecting group agent for hydroxyl functionalities in complex molecule construction.
• Research & Development: Serves as a standard or starting material in academic and industrial R&D for studying steroid metabolism and bioactivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Studies: Utilized in metabolic pathway research and enzyme inhibition studies related to steroid hormones.

Basic Information

Product Name	3α,17α-Bis(Trimethylsilyloxy)-5α-Androstane
CAS No.	10426-35-4
Molecular Formula	C24H46O2Si2
Molecular Weight	422.80 g/mol
Synonyms	5α-Androstane-3α,17α-diol bis(trimethylsilyl) ether; 3α,17α-Bis-O-(trimethylsilyl)-5α-androstane; Androstane-3α,17α-diol bis(TMS) ether; 5α-Androstane-3α,17α-diyl bis(oxy)bis(trimethylsilane); 3α,17α-Bis(trimethylsiloxy)-5α-androstane; 10426-35-4; 3,17-Bis(trimethylsilyloxy)-5-androstane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports the needs of cGMP-compliant manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.