Description

n-Trimethylsilylphthalimide is a versatile organosilicon reagent featuring a phthalimide-protected amine group. This compound is valued for its role as a key intermediate in organic synthesis, particularly in the preparation of silylated compounds and as a protective group for amines. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where silyl protection strategies are employed.
• Agrochemical Synthesis: Serves as a building block for creating novel pesticides and herbicides with modified biological activity.
• Peptide Chemistry: Acts as a protective agent for amino groups during solid-phase peptide synthesis (SPPS) and other coupling reactions.
• Material Science: Utilized in the production of silicon-containing polymers and advanced hybrid organic-inorganic materials.
• Cross-Coupling Reactions: Functions as a reagent in palladium-catalyzed cross-coupling reactions to introduce functional groups.
• Laboratory Research: A valuable reagent for academic and industrial R&D in developing new synthetic methodologies.

Basic Information

Product Name	n-Trimethylsilylphthalimide
CAS No.	10416-67-8
Molecular Formula	C₁₁H₁₃NO₂Si
Molecular Weight	219.31 g/mol
Synonyms	1-[(Trimethylsilyl)phthalimide; N-(Trimethylsilyl)phthalimide; Phthalimide, N-(trimethylsilyl)-; Trimethylsilylphthalimide; N-Trimethylsilylphthalimide; N-Phthalimidotrimethylsilane; TMS-Phthalimide; 1-(Trimethylsilyl)-1H-isoindole-1,3(2H)-dione
EINECS	233-892-8

Quality Control

Our n-Trimethylsilylphthalimide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications and supporting your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.