Description

N,o-Bis(Trimethylsilyl)Acetamide (CAS NO 10416-59-8) is a highly reactive organosilicon reagent primarily used as a powerful silylating agent. Its core value lies in its ability to efficiently protect reactive functional groups, such as hydroxyls and amines, by introducing the stable trimethylsilyl (TMS) group, thereby enabling complex synthetic transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for sensitive chemical synthesis.

Application

• Pharmaceutical Synthesis: As a key silylating agent in the protection of sensitive functional groups during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Analytical Chemistry: Used for derivatization in gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) to enhance the volatility and thermal stability of polar compounds for accurate analysis.
• Polymer & Material Science: Employed in the surface modification of inorganic materials and as a reagent in the synthesis of silicon-containing polymers and specialty silicones.
• Agrochemical Production: Facilitates the synthesis of advanced pesticide and herbicide intermediates by protecting reactive sites during critical reaction steps.
• Peptide & Carbohydrate Chemistry: Protects hydroxyl and amino groups in the synthesis of complex peptides, nucleotides, and sugar derivatives.
• Laboratory Reagent: Serves as a versatile reagent in research and development laboratories for exploratory organic synthesis and method development.

Basic Information

Product Name	N,o-Bis(Trimethylsilyl)Acetamide
CAS No.	10416-59-8
Molecular Formula	C8H21NOSi2
Molecular Weight	203.43 g/mol
Synonyms	BSA; N,O-Bis(trimethylsilyl)acetamide; Acetamide, N,N-bis(trimethylsilyl)-; 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine, N-acetyl derivative; BSA (silylating agent); N,O-Bis(trimethylsilyl)acetamide; Bis(trimethylsilyl)acetamide
EINECS	233-892-7

Quality Control

Our N,o-Bis(Trimethylsilyl)Acetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.417 - 1.421
Density (g/mL at 20°C)	0.83 - 0.87

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.