Description

N,n-Bis(Trimethylsilyl)Acetamide is a versatile and highly reactive organosilicon reagent primarily used as a powerful silylating agent. Its core value lies in its ability to efficiently protect hydroxyl, amino, and other labile functional groups, facilitating complex synthesis and analysis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, where precise derivatization and stability are paramount for process development and quality control.

Application

• Pharmaceutical Synthesis: As a key silylating agent for protecting reactive functional groups (e.g., -OH, -NH, -SH) during the multi-step synthesis of active pharmaceutical ingredients (APIs) and intermediates.
• Gas Chromatography (GC) Derivatization: Used to convert polar, non-volatile compounds (like sugars, acids, or steroids) into volatile trimethylsilyl (TMS) derivatives for accurate analysis by GC or GC-MS.
• Peptide and Nucleoside Chemistry: Protects sensitive amino and hydroxyl groups to prevent unwanted side reactions during the synthesis of complex biomolecules.
• Polymer and Material Science: Employed as a surface modifier or cross-linking agent to impart hydrophobic properties or alter the reactivity of material surfaces.
• Analytical Reagent: Serves as a derivatization reagent in various spectroscopic and chromatographic techniques to enhance detection sensitivity and compound stability.
• Agrochemical Manufacturing: Used in the synthesis of advanced pesticide and herbicide intermediates where selective protection of functional groups is required.

Basic Information

Product Name	N,n-Bis(Trimethylsilyl)Acetamide
CAS No.	10416-58-7
Molecular Formula	C8H21NOSi2
Molecular Weight	203.43 g/mol
Synonyms	BSA; N,O-Bis(trimethylsilyl)acetamide; Acetamide, N,N-bis(trimethylsilyl)-; 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine, N-acetyl derivative; Bis(trimethylsilyl)acetamide; N-[Trimethylsilyl]-N-(trimethylsilyl)acetamide; N,N-Bis(trimethylsilyl)acetamide; BSA (silylating agent)
EINECS	233-892-7

Quality Control

Our N,n-Bis(Trimethylsilyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing assay, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, this product should be stored in a cool, dry, and well-ventilated area, ideally under an inert atmosphere such as nitrogen or argon to maintain stability and prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%
Refractive Index (n20D)	1.417 - 1.423
Density (g/mL at 20°C)	0.83 - 0.87

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.