Description

Nortetrazepam CAS NO 10379-11-0 is a benzodiazepine derivative of significant interest in pharmaceutical research and development. This compound serves as a crucial intermediate for synthesizing novel therapeutic agents targeting the central nervous system. It is primarily required by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of anxiolytic and sedative-hypnotic medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in preclinical and clinical research to study structure-activity relationships (SAR) for new CNS-targeting drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Chemical Synthesis: Employed in organic synthesis for creating novel chemical entities with potential pharmacological activity.
• Metabolite Studies: Utilized in the study of drug metabolism and pharmacokinetics (DMPK) for related pharmaceutical compounds.

Basic Information

Product Name	Nortetrazepam
CAS No.	10379-11-0
Molecular Formula	C16H13ClN2O
Molecular Weight	284.74 g/mol
Synonyms	Desmethyletizolam; 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; 1-Methyldesalkylflurazepam; Nortetrazepam; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (common mis-assignment corrected); Nor-ETZ; Desmethyl Etizolam Metabolite
EINECS	Contact for details

Quality Control

Our Nortetrazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.