Description

Ethanone, 1-(1H-Benzimidazol-2-Yl)-2-Chloro- (9Ci) is a high-purity, specialized organic intermediate of significant importance in advanced chemical synthesis. This compound, identified by CAS No. 10227-64-2, serves as a critical building block for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Its unique benzimidazole-chloroethanone structure makes it an essential precursor for researchers and manufacturers developing active pharmaceutical ingredients (APIs) and high-performance crop protection agents.

Application

This versatile chemical intermediate is primarily utilized in sophisticated research and industrial synthesis processes. Key application areas include:

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzimidazole-based drug candidates, including potential antivirals, antifungals, and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of advanced fungicides and pesticides, leveraging the bioactive benzimidazole core.
• Organic Synthesis Building Block: Employed in research laboratories for constructing complex heterocyclic compounds and for introducing functionalized acetyl groups.
• Material Science Research: Investigated as a monomer or functional component in the development of specialty polymers and organic electronic materials.
• Dye and Pigment Intermediate: Serves in the synthesis of specialized dyes and pigments due to its conjugated system.

Basic Information

Product Name	Ethanone, 1-(1H-Benzimidazol-2-Yl)-2-Chloro- (9Ci)
CAS No.	10227-64-2
Molecular Formula	C9H7ClN2O
Molecular Weight	194.62 g/mol
Synonyms	2-Chloro-1-(1H-benzimidazol-2-yl)ethanone; 1-(1H-Benzimidazol-2-yl)-2-chloroethanone; 2-Chloro-1-(benzimidazol-2-yl)ethan-1-one; α-Chloro-2-benzimidazolyl methyl ketone; 2-Acetylbenzimidazole, 2'-chloro derivative; 2-(Chloroacetyl)benzimidazole; NSC 403119; 10227-64-2
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our chemical intermediates. Production of Ethanone, 1-(1H-Benzimidazol-2-Yl)-2-Chloro- is monitored through in-process checks and final batch analysis to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay (by HPLC), identity confirmation (IR, NMR), and impurity profiles. Our quality system is designed to support cGMP-compliant applications where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.