Description

1,3-Dimethyl-1,3-Bis(Trimethylsilyl)Urea is a highly effective silylating agent and dehydrating reagent used in organic synthesis. Its primary value lies in its ability to protect reactive functional groups, such as hydroxyls and amines, by converting them into their corresponding trimethylsilyl (TMS) derivatives, thereby facilitating complex multi-step reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the protection of sensitive functional groups during the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Employed as a coupling agent and for the silylation of amino acids to prevent unwanted side reactions and improve yields in peptide synthesis.
• Agrochemical Production: Facilitates the synthesis of advanced pesticide and herbicide intermediates by protecting reactive sites under harsh reaction conditions.
• Silicon Chemistry & Material Science: Serves as a precursor or silylating agent in the production of silicone-based polymers, coatings, and advanced functional materials.
• Analytical Derivatization: Used to derivative polar compounds for Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis, improving their volatility and thermal stability.
• Nucleoside & Carbohydrate Chemistry: Protects hydroxyl groups in the synthesis of modified nucleosides, nucleotides, and complex sugars.

Basic Information

Product Name	1,3-Dimethyl-1,3-Bis(Trimethylsilyl)Urea
CAS No.	10218-17-4
Molecular Formula	C9H24N2OSi2
Molecular Weight	232.47 g/mol
Synonyms	DMTMU; 1,3-Bis(trimethylsilyl)-1,3-dimethylurea; N,N'-Bis(trimethylsilyl)-N,N'-dimethylurea; Urea, 1,3-dimethyl-1,3-bis(trimethylsilyl)-; 1,1,3,3-Tetramethyl-1,3-bis(trimethylsilyl)urea; BSU; DMTMSU
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyl-1,3-Bis(Trimethylsilyl)Urea is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.