Description

Trimethylsilyl Methanesulfonate is a versatile organosilicon reagent primarily used as a powerful silylating agent and promoter in organic synthesis. Its high reactivity makes it a critical component for introducing the trimethylsilyl (TMS) protecting group and activating various functional groups under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precise control over reaction pathways is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Used as a silylating agent to protect hydroxyl and carboxyl groups during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Employed to activate carboxylic acids for peptide coupling reactions, facilitating the formation of amide bonds.
• Polymer & Material Science: Acts as a surface modifier and cross-linking agent in the production of silicone-based polymers and specialty coatings.
• Analytical Derivatization: Utilized in gas chromatography (GC) and mass spectrometry (MS) to derivative polar compounds, improving their volatility and detection.
• Catalyst & Reagent Preparation: Serves as a precursor or additive in the preparation of Lewis acid catalysts and other specialty reagents.
• Nucleoside & Carbohydrate Chemistry: Protects sensitive hydroxyl groups during the synthesis of nucleosides, nucleotides, and complex sugars.

Basic Information

Product Name	Trimethylsilyl Methanesulfonate
CAS No.	10090-05-8
Molecular Formula	C4H12O3SSi
Molecular Weight	152.29 g/mol
Synonyms	Methanesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Methanesulphonate; TMS Methanesulfonate; TMS Mesylate; (Trimethylsilyl)methyl Sulfonate; Trimethylsilyl Ester of Methanesulfonic Acid; Silylating Agent TMS-OMs
EINECS	233-224-5

Quality Control

Our Trimethylsilyl Methanesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 1.0% (total)
Density (at 20°C)	~1.05 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.