Description

Benzene, 1-Isocyano-2,4-Dimethoxy- (9Ci) is a specialized aromatic isocyanide derivative characterized by its dimethoxy-substituted benzene ring. This compound is a valuable synthetic building block, prized for its reactivity as an isocyanide in multi-component reactions and as a ligand precursor in organometallic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of heterocyclic compounds and active pharmaceutical ingredients (APIs) via Passerini and Ugi multi-component reactions.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides, leveraging its isocyanide functionality.
• Organometallic Catalyst Ligand: Serves as a precursor for isocyanide ligands used in palladium, rhodium, and other transition metal catalysis for cross-coupling reactions.
• Material Science Research: Used in the development of functional polymers, dendrimers, and smart materials where the isocyano group enables specific conjugation or polymerization pathways.
• Chemical Biology Probe Development: Utilized in bioorthogonal chemistry and for labeling biomolecules due to the unique reactivity of the isocyanide group.
• Academic & Industrial R&D: A fundamental reagent in methodological organic chemistry research for discovering new synthetic transformations.

Basic Information

Product Name	Benzene, 1-Isocyano-2,4-Dimethoxy- (9Ci)
CAS No.	1984-21-0
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	1-Isocyano-2,4-dimethoxybenzene; 2,4-Dimethoxyisocyanobenzene; 2,4-Dimethoxyphenyl isocyanide; Isocyanic acid, 2,4-dimethoxyphenyl ester; 2,4-Dimethoxybenzene isocyanide; 2,4-Dimethoxyphenyl isonitrile
EINECS	Contact for details

Quality Control

Our Benzene, 1-Isocyano-2,4-Dimethoxy- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR), to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity, allow the container to reach ambient temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.